In a battle featuring two teams coming off wins, the (8-3) will meet the (10-1). The 49ers have taken three in a row, the Eagles five in a row. San Francisco is favored by 3 points. The predicted point total for the matchup is 46.5. Odds Betting Lines49ers vs Eagles Betting Information updated as of November 28, Jazz Chisholm Jersey 2023, 11:33 PM ET.FavoriteSpreadFavorite Spread OddsUnderdog Spread OddsTotalOver Total OddsUnder Total Odds49ers-3-102-11846.5-110-110ADVERTISEMENT 49ers vs. Eagles Prediction PickPick ATS: San Francisco (-3)Pick OU: Over (46.5)Prediction: San Francisco 26 - Philadelphia 21How to Watch San Francisco vs. PhiladelphiaGame Date: Sunday, December 3, 2023Time: 4:25 PM ETVenue: Lincoln Financial FieldLocation: Philadelphia, PennsylvaniaTV: Watch on FOX49ers vs. Eagles Recent MatchupsOver their last five meetings, Philadelphia has put up three wins against San Francisco.Over their last five head-to-head matchups, Philadelphia has put up 135 points, while San Francisco has tallied 91.San Francisco Betting InfoAgainst the spread, San Francisco is 6-5-0 this season.The 49ers have covered the spread five times this season (5-5 ATS) when playing as at least 3-point favorites.San Francisco games in 2023 have hit the over five times in 11 opportunities (45.5%).When playing as the moneyline favorite, the 49ers are 8-3 (winning 72.7% of the time).San Francisco is 7-3 (winning 70% of its games) when playing as a moneyline favorite of -155 or shorter.The implied probability Miami Marlins Blank Jersey for this matchup, considering the moneyline, gives the 49ers a 60.8% chance to win.49ers StatsStatAverage (Total)RankPa s yards250.1 (2,751)8Rush yards136 (1,496)7Points scored28.2 (310)5Pa s yards against213.3 (2,346)12Rush yards against82 (902)2Points allowed15.5 (170)1San Francisco's Key PlayersOffenseChristian McCaffrey's rushing stat line this season includes 939 yards (first in the NFL) and 11 TDs. He's averaging 85.4 yards per game and 4.9 per attempt (ninth in the NFL).McCaffrey has 58 targets, 48 catches, 389 receiving yards and five TDs in the pa sing game. has 2,871 pa sing yards (eighth in the NFL), 19 touchdowns (seventh in the NFL) and six interceptions this year. He has completed 70.2% of his attempts, averaging 261 yards per game and 9.4 per attempt.He has also rushed for 122 yards (fourth on the 49ers) and added two touchdowns on the ground, while averaging 11.1 rushing yards per game. has five touchdown catches this season, and has 45 catches for 881 yards (10th in the NFL) on 65 targets, while averaging 4.5 catches and 88.1 yards per game. has 46 receptions for 667 yards and five touchdowns. He's been targeted 61 times in the air attack, and averages 4.2 receptions and 60.6 yards through 11 games played.DefenseOver on defense, has three interceptions (seventh in the NFL) to go with 95 tackles, five TFL, two sacks, and eight pa ses defended in 2023. has eight sacks (first on the 49ers) as well as nine TFL and 33 tackles. has collected 79 tackles, five TFL, and 1.5 sacks this year. He's second on the 49ers in tackles. has two interceptions with 51 tackles, one TFL, and 15 pa ses defended.Philadelphia Betting InfoPhiladelphia have put together a 7-2-2 record against the spread this year Miami Marlins Jersey .This season, Philadelphia games have hit the over six times.The Eagles won the only game they've played as the underdog this season.Philadelphia has not entered a game this season with longer moneyline odds than +130.The moneyline for this contest implies a 43.5% chance of a victory for the Eagles.Eagles StatsStatAverage (Total)RankPa s yards231 (2,541)13Rush Trevor Richards Jersey yards133.3 (1,466)8Points scored28.2 (310)5Pa s yards against255.7 (2,813)29Rush yards against85.3 (938)3Points allowed22.4 (246)20Philadelphia's Key PlayersOffenseThrough 11 games played this year, has ama sed 2,697 pa sing yards, while throwing 18 touchdowns (10th in the NFL) against 10 interceptions and completing 67.6% of his attempts.He's added 410 yards on the ground (second on the Eagles), while scoring 11 rushing touchdowns. He's averaging 37.3 yards per game and 3.6 per attempt. has put together a 2023 campaign that includes 73 catches (10th in the NFL) for 1,050 yards (fourth in the NFL) and seven receiving touchdowns (fifth in the NFL) over 11 games played. He has been on the receiving end of 105 targets and is averaging 6.6 receptions per game.D'Andre Swift is averaging 70 rushing yards per game this season (770 total yards to rank fourth in the NFL), while scoring four rushing touchdowns.Swift's statistic output includes 34 receptions (3.1 per game) on 39 targets for 201 yards (18.3 per game) and one receiving touchdown. has 738 receiving yards and five touchdowns from 55 receptions after getting 76 targets.DefenseReed Blankenship has ama sed two TFL, 70 tackles, and two interceptions over nine games in 2023. has registered 84 tackles and one interception over 10 games.Over the 2023 campaign, has 30 tackles, six TFL, and 6.5 sacks through 11 games. has 47 tackles, nine TFL, three sacks, and one pa s defended.Patrick Mahomes tops Mahomes Mountain (Nick's QB Tiers) thru Week 12 | First Things First Nick Wright, Greg Jennings, Chris Brou sard and Kevin Wildes reveal the latest edition of Mahomes Mountain (Nicks QB Tiers) entering Week 12. Notable movements include Patrick Mahomes at the Lewis Brinson Jersey top, flanked by Dak Prescott Jalen Hurts. Trevor Lawrence, Lamar Jackson and C.J. Stroud round out the Top 6 QBs in Nicks NFL Tiers.