Teams that don't often face one another will meet in a key interconference battle when the take on the on Monday Night Football. The teams have met a dozen times since the 1970 AFL-NFL merger, with seven of Ka'imi Fairbairn Jersey the games decided by a touchdown or le s. Los Angeles has won four of five games played in New Orleans. New Orleans is tied for fifth in the league with five sacks allowed for 40 yards, while Los Angeles is tied for 14th with eight sacks allowed for 39 yards.Kickoff from the Superdome is set for 8:15 p.m. ET. Los Angeles will be without running back(hamstring), while New Orleans will be without star wideout. New Orleans is a seven-point favorite in the latest Saints vs. Chargers odds from William Hill after the line opened at 7.5, while the over-under is 49.5. Before making any Chargers vs. Saints picks, .The model, which simulates every NFL game 10,000 times, is up over $7,300 for $100 players on top-rated since its inception five-plus years ago. It's off to a strong 7-4 roll on top-rated NFL picks this season. The model enters Week 5 on an incredible 103-69 run on top-rated NFL picks that dates back to the 2017 season.The model ranked in the Top 10 on NFLPickWatch in three of the past four years on straight-up NFL picks and beat more than 95 percent of CBS Sports office pool players three times during that span. Anyone who has followed it is way up.Now, the model has set Sam Cooper Jersey its sights on . You can . Here are the from William Hill and trends for Saints vs. Chargers: Chargers vs. Saints spread: Saints -7Chargers vs. Saints over-under: 49.5 pointsChargers vs. Saints money Phillip Dorsett II Jersey line: Chargers +260, Saints -320LAC: Has allowed a red zone touchdown percentage of 42.9, third-best in the NFLNO: Over has hit in all four Saints games this seasonWhy the Saints can cover New Orleans' defense is ranked sixth in the NFL, allowing 334.3 yards per game. A big reason for that is the play of defensive end . He had a sack last week and had a sack and a forced fumble in the last meeting against the Chargers.Jordan will look for his third game in a row with a sack against Los Angeles. He also has a sack in two of his last three games on Monday Night Football.Linebacker is also a difference-maker with 26 tackles, including 20 solo. He has two sacks for 20 yards and four tackles for lo s to go along with one pa s breakup. Davis has at least six tackles in two of his last three games against the Chargers and has five pa s breakups in his past four games on MNF.Why the Chargers can cover Rookie quarterback will try to pick up the slack after the lo s of Ekeler. Herbert had a strong game last week against the , completing 20 of 25 pa ses (80 percent) for 290 yards and a career-high three touchdowns. He is looking for his fourth game in a row with 275 or more pa sing yards and a touchdown pa s. Herbert became the first rookie since in 2017 to throw two touchdown pa ses of 50 or Isaac Yiadom Jersey more yards in a game.One of Herbert's top targets is tight end , who is second on the team with 18 receptions for 245 yards (13.6 average). He has four explosive plays of 20 or more yards with 11 first-down conversions. Henry has Tae Davis Jersey five or more catches in five of his last six games. He had a receiving touchdown in his last meeting against the Saints.How to make Saints vs. Chargers picks SportsLine's model is leaning over the total. In fact, it says Herbert will throw for nearly 300 yards and two touchdowns, while Brees will throw for nearly 250 yards and at least two scores. It has also generated an against-the-spread pick that cashes in well over 50 percent of simulations..So who wins Chargers vs. Saints on Monday Night Football? And which side of the spread cashes in well over 50 percent of simulations? , and find out.